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Grey’s Anatomy Season 23 Premiere Teases Major Character Exit

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The carousel never stops turning, and Grey’s Anatomy is never devoid of drama.

Naturally, the season 23 premiere of the Shondra Rhimes series Oct. 15 kicked off with a bang, not only teasing a possible exit for Dr. Jo Wilson, (Camilla Luddington), but also pushing one, or two, of epi into every fan by revealing Dr. Simone Griffith (Alexis Floyd) is pregnant.

Before getting to the major traumas, though, some of the other Grey Sloan doctors proved they’re still taking many visits to the on-call room. Case in point: cardiothoracic head Dr. Winston Ndugu (Anthony Hill) and resident Dr. Jules Millin (Adelaide Kane) are still picking, choosing and loving to sneak around their fellow hospital staff given their inappropriate romantic relationship.

Meanwhile, Meredith Grey (Ellen Pompeo) popped into Grey Sloan long enough to see that things are going downhill following the establishment of a new VIP floor, with the help of new Chief of Surgery Dr. Seth Norton (James Wolk). Unfortunately, Meredith’s wedding plans with Nick Marsh (Scott Speedman) seem to be all halted for now—as Speedman did not appear in the episode and Meredith was not sporting any kind of engagement ring in the episode.

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But rest assured, Grey’s executive producer Meg Marinis confirmed the R.J. Decker star will return to the OR floor soon enough—and vows will be written on a Post-It at the very least.

“Yes, we will see Nick,” Marinis told Deadline in an interview published Oct. 15. “The engagement is still on. Meredith Grey has never really worn a ring, even when she was with Derek. So, she’s not necessarily a ring wearer, but that’s not to say that once they get married they may have wedding bands. We’ll pick up that story though, don’t worry.”

As for Dr. Benson Kwan (Harry Shum Jr.), his firing has worked out perfectly for the actor. Shum Jr. has been able to seamlessly continue his tenure on Dancing With the Stars while his Grey’s Anatomy counterpart spent his premiere screentime embracing unemployment by playing video games.

Anne Marie Fox/Disney

And as for those major cliffhangers at the end of the episode? Griffith still hasn’t figured out how to tell her boyfriend Wes Bryant (Trevor Jackson) that she cheated on him with her ex Dr. Lucas Adams (Nikho Terho) last season—and to make matters worse her pregnancy test comes back positive at the end of the episode.

For those who have been watching Griffith’s love triangle unfold from the OR gallery, it may seem likely that her baby’s father is Lucas, considering she and Wes had been so careful about using condoms while having sex. But Marinis emphasized that sometimes hoofbeats do, in fact, mean zebras and not horses.

“It does not automatically mean it is Lucas,” Marinis told Deadline. “It is a big old question, and it’s messy.”

Finally, the tease of Jo’s exit was the very last thing said in the episode. While her husband Dr. Atticus Lincoln (Chris Carmack) sneakily steals some of her old prescriptions just before she walks in the door, Jo delivers the real blow—admitting that she simply can’t recover from her birth trauma while working at Grey Sloan.

As she tells her husband just before the credits role, “I quit.”

If you need some time to recover from the latest Grey’s Anatomy episode, keep reading for more of the series’ most shocking moments…

From Booty Call to BossIncoming surgical intern Meredith Grey (Ellen Pompeo) was thrown for quite a loop in Grey’s Anatomy‘s series premiere when she learned that the hunky one-night-stand she picked up at the bar played by Patrick Dempsey was actually her new boss, renowned surgeon Dr. Derek Shepherd. Oops.

Addison’s ArrivalFans were just as stunned as poor Meredith in the season one finale when Addison Montgomery (Kate Walsh) waltzed into Seattle Grace and right up to Mer and Derek, introducing herself with the now iconic “You must be the woman who’s been screwing my husband.”

Peter “Hopper” Stone/Walt Disney Television via Getty Images

Bombs AwayWhen Grey’s Anatomy was given the plum post-Super Bowl slot in its second season, fans watched tensely as Meredith decided to shove her hand into a body cavity containing a live explosive to keep it from detonating. And just as we began to breathe a sigh of relief when bomb squad chief Dylan (guest star Kyle Chandler) began to walk away with the removed explosive, it blew, taking the poor guy out in the process.

Scott Garfield/Disney General Entertainment Content via Getty Images

Denny’s DemiseFans watched as Izzie (Katherine Heigl) fell in love with the effortlessly charming Denny Duquette (Jeffrey Dean Morgan) as he awaited a much-needed heart transplant throughout the second half of season two, falling for him right along with her. And when her wild plan to cut his LVAD wire to move him up the transplant list failed spectacularly, resulting in his death in the season finale, it was confirmed that Grey’s Anatomy was not here to give us the happy endings we wanted.

Meredith’s Near-Death ExperienceWhat was more surprising during season three’s big ferry accident: Meredith nearly drowning after being knocked into freezing cold waters at the accident site or her later admission that she’d given up trying to survive?

Lexie’s ArrivalAt the end of season three, a surgical intern named Lexie (Chyler Leigh) arrived at Seattle Grace, first meeting Derek the night prior to starting at the hospital in a moment that mirrored his first interaction with Mer two seasons prior (but, thankfully, did not end with them sleeping together) and then introducing herself to George O’Malley (T.R. Knight) in the intern locker room. Oh, and her last name? Why, Grey, of course. And just like that, Meredith’s younger half-sister, one of two daughters raised by her father Thatcher and his second wife Susan, was added to the mix.

Ghost DennyTwo and a half seasons after he’d perished, Denny was back and his ghost was…having sex with Izzie. In one of the most ludicrous moments in the show’s history, Ghost Denny was used to signal to viewers and to Izzie herself that something was wrong. That something was ultimately proven to be stage IV metastatic melanoma, which had spread to, among other places, her brain.

It’s GeorgeWhile fans were expecting Izzie to bite the bullet in the season five finale, the fact that no one could find George should’ve clued us into the fact that something was up with poor O’Malley. When Meredith finally realized what the John Doe who’d been hit by a bus while trying to save a woman on the street was writing in her hand–007, his cruel nickname in earlier seasons–she tried to alert the surgeons working on him, but it was too late. He flatlined and died.

The ShootingFile this one under: The mist disturbing episode in Grey’s history. In the season six finale, the grieving husband of a deceased patient arrived at the hospital, fresh off its merger with neighboring Mercy West, with a loaded gun and nothing left to live for. A few doctors were murdered, several more injured, and the image of Bailey (Chandra Wilson) being dragged by her feet out from under a patient’s bed will forever haunt us. Thankfully, she survived. Mer and Derek’s baby wasn’t so lucky. After he was shot, she believed he’d died and had a traumatic miscarriage.

The Plane CrashTwo seasons after the horrific hospital shooting, Shonda Rhimes decided it was time to torture a handful of docs yet again. In the eighth season finale, a plane carrying Meredith, Derek, Cristina Yang (Sandra Oh), Lexie, Mark Sloan (Eric Dane) and Arizona Robbins (Jessica Capshaw), traveling to Boise, Idaho to perform surgery on conjoined twins, crashed in the wilderness, leaving them stranded and wounded, with no one at home even knowing they’d gone down. The accident claimed Mark and Lexie’s lives and Arizona’s leg, while nearly leaving Derek’s hand permanently injured.

Burke’s ReturnHow would Grey’s send off Mer’s person Cristina at the end of season 10 after Sandra Oh decided to move on? Why, by having ex Preston Burke (Isaiah Washington) pop back up after leaving her at the altar in season three to offer her his hospital in Switzerland. That the show brought Washington back after his highly contentious exit, which involved him referring to co-star T.R. Knight by a heinous gay slur, was truly surprising.

Maggie’s ArrivalAs the show said goodbye to Cristina in the season 10 finale, it welcomed her replacement as the head of cardio-thoracic surgery, Dr. Maggie Pierce. And when the character, played by Kelly McCreary, revealed to Richard (James Pickens Jr.) in the episode’s final moments that she was Dr. Ellis Grey’s daughter, asking if he knew the legendary doctor, he wasn’t the only one stunned to learn that he had a daughter and that Mer had another sister.

ABC/Kelsey McNeal

Derek’s DepartureLiterally no one saw it coming when, with a handful of episodes left to air in season 11, Derek was killed off, the victim of a head-on collision just after rescuing a family on the side of the road involved in a car crash of their own. Patrick Dempsey had just recently extended his contract on the show, making his departure truly unexpected. Killing off Mer’s husband may have been Shonda Rhimes‘ only feasible option to get rid of the character in a way that didn’t render an 11-year love story completely worthless, but that didn’t mean it hurt any less.

Meredith’s AttackAs if Mer hadn’t been through enough up to this point, in the ninth episode of season 12, she was violently attacked by a patient in a brutal episode that saw her jaw broken and then wired shut in order to restore her hearing. Her panic attack when her kids won’t see her during her recovery was a stunning moment of acting from Ellen Pompeo.

Alex’s DepartureHow would the show explain Alex Karev’s sudden absence after original star Justin Chambers walked away from his role midway through season 16? By having him write letters to wife Jo (Camilla Luddington), Mer and Bailey explaining that he’d gotten in contact with Izzie years after she ghosted and sent him divorce papers, only to learn that she’d been raising their twins all these years on a farm somewhere and he’d chosen his newfound family over his life in Seattle. If anyone tells you they saw that coming, we’ll show you a liar.

The Death of Dr. DeLucaIn season 17, fans watched as Dr. Andrea “Andrew” DeLuca (Giacomo Gianniotti) met his untimely end. After overcoming his mental health struggles, DeLuca found himself as an attending at Grey Sloan Memorial Hospital. Yet, in typical Grey’s fashion, Dr. DeLuca’s back-on-track life was cut tragically short when he was stabbed by a human trafficker’s accomplice.

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