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Watch: Christina Applegate Addresses Health Concerns Amid MS Battle

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Christina Applegate Shares Pic of “Weird Spot” on Cheek Amid MS Battle

Watch: Christina Applegate Addresses Health Concerns Amid MS Battle

Christina Applegate is providing a candid update.

The Married… With Children alum—who was diagnosed with multiple sclerosis in 2021—shared a video of herself with a new look, as she revealed her latest hair transformation and a new facial marking.

In the clip posted to her Instagram Sept. 21, Applegate posed for the camera in jeans and a black zip-up hoodie that hung off her shoulder in order to show off her new bright blonde hair color. And as she turned her head to the side to give people a better look of the highlighted hue, a darker mark on her cheek also became visible.

“Fresh hair color, new weird spot on my cheek haha,” Applegate captioned the footage before going on to thank her stylist Dave Stanwell. “Thank you @davestanwell for brightening up my cloudy day. Love you and love to you all out there.”

Shortly after, the 54-year-old also uploaded a selfie with the skin pigmentation on display to her Instagram Stories, though she didn’t specify what caused the discoloration.

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A Look at Christina Applegate’s Unforgettable Roles

Of course, Applegate is no stranger to being vulnerable about where her health stands. Back in March, the Dead to Me star detailed in her memoir, You With the Sad Eyes, what it’s like living with the side effects of MS, a disorder which affects the body’s immune system.

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“When I wake up, I often can’t get my arm to move far enough to grab the cup of water by my bed or my phone from its charger,” Applegate wrote in the book, per Today. “One of the worst side effects of the illness is the exhaustion. It feels as though I’ve been on a three-day-long sleepless bender.”

But amid those difficulties, the actress noted that she still finds moments of joy, like when she does her daily school drop-off with her 15-year-old daughter Sadie, who she shares with husband of 13 years Martyn LeNoble.

Photo by Matt Winkelmeyer/Getty Images for Critics Choice Association

“It’s my favorite thing to do. It’s the only time we have together by ourselves,” she explained. “I tell myself, ‘Just get her there safely and get home so you can get back into bed.’ And that’s what I do.”

For more on Applegate’s health journey, keep reading.

David Fisher/Shutterstock

Health JourneyChristina Applegate shared she was diagnosed with multiple sclerosis in 2021.”Hi friends. A few months ago I was diagnosed with MS,” she shared on her social media channels that August. “It’s been a strange journey. But I have been so supported by people that I know who also have this condition. It’s been a tough road. But as we all know, the road keeps going. Unless some a–hole blocks it.”

Stewart Cook/Shutterstock

First Public Appearance”Oh, by the way, I have a disease,” she joked during her November 2022 Hollywood Walk of Fame induction ceremony, her first public appearance since her MS diagnosis. “Did you not notice? I’m not even wearing shoes.”

Daniele Venturelli/WireImage

Early SymptomsApplegate believes her MS journey actually began “six or seven years” before her 2021 diagnosis.”I noticed, especially the first season [of Dead to Me], we’d be shooting and my leg would buckle,” Applegate explained during a March 2024 interview on Good Morning America. “I really just put it off as being tired, or I’m dehydrated, or it’s the weather. Then nothing would happen for months, and I didn’t pay attention.”By the time she was shooting the Netflix series’ third and final season, the actress said she was “being brought to set in a wheelchair.””I couldn’t move that far,” she recalled, “so I had to tell everybody because I needed help.”

X/Christina Applegate

Making MovesThe Dead to Me star captioned this photo of her cane collection amid her battle with MS: “Walking sticks are now part of my new normal.”

Matt Baron/BEI/Shutterstock

Strong StatementJoined by her daughter Sadie Grace LeNoble, Applegate had a simple message for multiple sclerosis while attending the 2023 SAG Awards: “F U MS.”And she’s not the only one experiencing strong feelings towards the illness. “In my situation, Sadie only knew me as healthy and a runner and a Pelotoner and a dancer—and she only knew that,” Applegate explained to friend Jamie-Lynn Sigler on an August 2025 episode of their MeSsy podcast. “So then when this came about in 2021, she was, like, stoic about it.”Yet, “I see her look at me when I’m in bed,” Applegate continued, “and can’t quite move or, I want to go say goodnight to her in her room but I can’t quite get down the hallway for whatever reason my legs aren’t working that day.” The whole experience has “broken” her teen, Applegate noted. “It was like losing the mom she had to this f–king thing. And the more she’s gotten older now, I think the more it’s hurting her.”

Kevin Winter/Getty Images

Just JokesAfter a receiving standing ovation at the 2023 Emmys, the Married…With Children alum quipped, “You’re totally shaming me with disability by standing up.”

Matt Winkelmeyer/Getty Images for Critics Choice Association

Healing Through Humor”I make these jokes because if I don’t, I’ll suffocate,” Applegate shared on a March 2024 episode on Armchair Expert, explaining why she often pokes fun at her condition. “I’ll be done.”So, yes, she’s going to talk about the fact that she’s already purchased burial plots. “My friend and I are going to go take a picnic there,” Applegate revealed on a March 2026 episode of NPR’s Wild Card. “It’s really pretty where it is.” She just has to pick out a tree “’cause it’s really sunny,” she continued. “And I want my visitors to not be sweating.”

Kevin Mazur/Getty Images for Critics Choice Association

MS On Her Mind”I have 30 lesions on my brain,” she noted on Armchair Expert. “My biggest one is behind my right eye, so my right eye hurts a lot.”Legions are caused by the immune system attacking the myelin sheath around nerves, according to the Multiple Sclerosis Trust.

Randy Holmes/Disney via Getty Images

Getting CandidApplegate hasn’t held back when it comes to sharing her journey. “It sucks,” the Anchorman actress told late night talk show host Jimmy Kimmel of her daily struggles with MS. “I’m not going to lie. I think anyone who has MS isn’t going to be like, ‘This is the best thing that ever happened to me!'”Besides, she’d taken that tack when discussing her breast cancer battle back in 2008. “I went out, and I was the good girl talking about ‘Oh, I love my new boobs’ that are all scarred and f–ked up. What was I thinking?” she said on Armchair Expert. “Everything I was saying was a freaking lie. It was me trying to convince myself of something, and I think that did no service to anyone.” While she started a foundation and “raised millions of dollars for women to get MRIs who were at high risk,” she noted, “at the back of it, I was taking off my bra and crying every night. And I wish that I had said that.”

Monica Schipper/WireImage

In Her BubbleWhen talking about her day-to-day life with the disease, Applegate told Good Morning America in March 2024, “I live kind of in hell.””But I might get to a place where I function a little bit better,” she added. “Right now, I’m isolating, and that’s kind of how I’m dealing with it—by not going anywhere because I don’t want to do it. It’s hard.”

KMazur/WireImage

The Sweetest SupportChristina credited her Sweetest Thing costar Selma Blair—who was diagnosed with MS in 2018—for urging her to get tested for the disease.”She said, ‘You need to get checked for MS,'” Christina recalled during her GMA interview. “If not for her, it could’ve been way worse.”

Phillip Faraone/Getty Images

Friendship Never DiesApplegate confirmed that Dead to Me will likely be her last onscreen credit, telling Vanity Fair in May 2023, “I can’t even imagine going to set right now.””I’m probably not going to work on-camera again, but I’m so glad that I went out with someone who is by far the greatest actress I’ve ever worked with in my entire life,” she said of costar Linda Cardellini, “if not the greatest human I’ve ever known.

Charles Sykes/Bravo; Emma McIntyre/Getty Images for Netflix

The Dirty TruthFor Applegate, contracting sapovirus—a virus commonly transmitted through fecal-oral contact—meant having to rely on adult diapers. “I woke up at three o’clock in the morning in a pool of s–t,” she explained on an April 2024 episode of her MeSsy podcast. “I didn’t know what happened, and having MS at three o’clock in the morning and trying to change your sheets, it’s not fun. But this brings me to my next point, which we can talk about: I’m wearing diapers.”Their discussion was “so liberating,” her co-host Sigler noted. “This is something you do by yourself and it feels terrible when you’re doing it. I’ve done that hundreds of times in my MS journey through the years when I’ve experienced a flair or when I was sick.”

Christina Applegate/Instagram

Dark Matter”I am in a depression right now, which I don’t think I’ve felt for years,” Applegate confessed to Sigler on another 2024 episode of their MeSsy podcast. “Like a real, f–k it all, like real depression where it’s kind of scaring me too a little bit because it feels really fatalistic.”Three years into her diagnosis, she continued, “And I’m still sitting here like ‘Boohoo, woe is me.’ I’m still mad about it.” But the truth was, added, “I don’t enjoy living—I don’t enjoy things anymore.”

Tibrina Hobson/WireImage

Screaming PainApplegate acknowledged the reality of living with MS can be grim. “Everybody has different ways of it showing up,” she noted on a November 2024 episode of her podcast. “I lay in bed screaming. Like, the sharp pains, the ache, the squeezing.”At times, the discomfort even makes it hard for her to enjoy her one source of comfort, the reality TV that at times is “on 24/7 in my room,” she noted. But, “I can’t even pick up my phone sometimes,” Applegate added, “because now it’s traveled into my hands. So I’ll try to go get my phone or get my remote to turn on the TV or whatever, and sometimes I can’t even hold them.”

Kevin Winter/Getty Images

Checking InSince her 2021 diagnosis, Applegate has gotten used to the feel of an open-front gown. “I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain,” she relayed on her pocast in March 2025. “That is unimaginable, OK? They’ve done every test known to man on me, put so much radiation into my body from CT scans to everything else.”In the plus column, she noted, she has connected some of her gastro issues to her larger illness. “I have noticed that—and I’m going to be really honest—if I have to poop, I puke,” she detailed. “And when I puke, I get all the pain and then all the things happen.” Mere months after her hospital confession, Applegate was checking back in. Returning from a family trip to Europe, “I’m like, ‘I wanna be admitted. I’m staying here because I want answers,'” she recounted that August of what she told staff. “‘I want every test that you can possibly think of or ones that you haven’t even thought of, and I want them done.'”Following a middle-of-the-night CT, she learned, “I had kidney infections.”

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