Haston JC, O’Laughlin K, Matteson K, Roy S, Qvarnstrom Y, Ali IKM, et al. The epidemiology and clinical features of non-keratitis Acanthamoeba infections in the United States, 1956–2020. Open Forum Infect Dis. 2023;10:ofac682. DOIPubMedGoogle Scholar
Cope JR, Landa J, Nethercut H, Collier SA, Glaser C, Moser M, et al. The epidemiology and clinical features of Balamuthia mandrillaris disease in the United States, 1974–2016. Clin Infect Dis. 2019;68:1815–22. DOIPubMedGoogle Scholar
Martinez AJ, Visvesvara GS. Free-living, amphizoic and opportunistic amebas. Brain Pathol. 1997;7:583–98. DOIPubMedGoogle Scholar
Shehab KW, Aboul-Nasr K, Elliott SP. Balamuthia mandrillaris granulomatous amebic encephalitis with renal dissemination in a previously healthy child: case report and review of the pediatric literature. J Pediatric Infect Dis Soc. 2018;7:e163–8. DOIPubMedGoogle Scholar
Matin A, Siddiqui R, Jayasekera S, Khan NA. Increasing importance of Balamuthia mandrillaris. Clin Microbiol Rev. 2008;21:435–48. DOIPubMedGoogle Scholar
Siddiqui R, Matin A, Warhurst D, Stins M, Khan NA. Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity. Antimicrob Agents Chemother. 2007;51:4471–3. DOIPubMedGoogle Scholar
Matin A, Siddiqui R, Jung SY, Kim KS, Stins M, Khan NA. Balamuthia mandrillaris interactions with human brain microvascular endothelial cells in vitro. J Med Microbiol. 2007;56:1110–5. DOIPubMedGoogle Scholar
Matin A, Stins M, Kim KS, Khan NA. Balamuthia mandrillaris exhibits metalloprotease activities. FEMS Immunol Med Microbiol. 2006;47:83–91. DOIPubMedGoogle Scholar
Jayasekera S, Matin A, Sissons J, Maghsood AH, Khan NA. Balamuthia mandrillaris stimulates interleukin-6 release in primary human brain microvascular endothelial cells via a phosphatidylinositol 3-kinase-dependent pathway. Microbes Infect. 2005;7:1345–51. DOIPubMedGoogle Scholar
Visvesvara GS, Martinez AJ, Schuster FL, Leitch GJ, Wallace SV, Sawyer TK, et al. Leptomyxid ameba, a new agent of amebic meningoencephalitis in humans and animals. J Clin Microbiol. 1990;28:2750–6. DOIPubMedGoogle Scholar
Spottiswoode N, Haston JC, Hanners NW, Gruenberg K, Kim A, DeRisi JL, et al. Challenges and advances in the medical treatment of granulomatous amebic encephalitis. Ther Adv Infect Dis. 2024;11:20499361241228340. DOIPubMedGoogle Scholar
Centers for Disease Control and Prevention. Clinical care of Balamuthia infection. 2025 [cited 2025 Apr 1]. https://www.cdc.gov/balamuthia/hcp/clinical-care
Laurie MT, White CV, Retallack H, Wu W, Moser MS, Sakanari JA, et al. Functional assessment of 2,177 U.S. and international drugs identifies the quinoline nitroxoline as a potent amoebicidal agent against the pathogen Balamuthia mandrillaris. MBio. 2018;9:e02051–18. DOIPubMedGoogle Scholar
Naber KG, Niggemann H, Stein G, Stein G. Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections. BMC Infect Dis. 2014;14:628. DOIPubMedGoogle Scholar
Spottiswoode N, Pet D, Kim A, Gruenberg K, Shah M, Ramachandran A, et al. Successful treatment of Balamuthia mandrillaris granulomatous amebic encephalitis with nitroxoline. Emerg Infect Dis. 2023;29:197–201. DOIPubMedGoogle Scholar
Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372. DOIPubMedGoogle Scholar
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372. DOIPubMedGoogle Scholar
Mei J, Sheng F, Zhang C, Chen X. Imaging monitoring of Balamuthia granulomatous amoebic encephalitis. Clin Neurol Neurosurg. 2025;254:108917. DOIPubMedGoogle Scholar
Lehmer LM, Ulibarri GE, Ragsdale BD, Kunkle J. Cutaneous Balamuthia mandrillaris infection as a precursor to Balamuthia amoebic encephalitis (BAE) in a healthy 84-year-old Californian. Dermatol Online J. 2017;23:13030/qt8c8720qm. DOIPubMedGoogle Scholar
Edminster SY, Rebbe RW, Khatchadourian C, Hurth KM, Mathew AJ, Huss-Bawab J, et al. The role of plasma metagenomic sequencing in identification of Balamuthia mandrillaris encephalitis. Acta Neuropathol Commun. 2025;13:60. DOIPubMedGoogle Scholar
Tello-Zavala MC, Bravo-Oro A, Falcón-Escobedo R. Central nervous system infection in an immunocompetent Mexican child. Pediatr Infect Dis J. 2014;33:991, 995–6.PubMedGoogle Scholar
Li Q, Yang XH, Qian J. September 2004: a 6-year-old girl with headache and stiff neck. Brain Pathol. 2005;15:93–5. DOIPubMedGoogle Scholar
Atay Ünal N, Kuzucu P, Bedir Demirdağ T, Aykur M, Günsoy Kiliç Y, Güdeloğlu E, et al. 12-year-old boy with fever, headache and vomiting. Pediatr Infect Dis J. 2024;43:88–90. DOIPubMedGoogle Scholar
Qvarnstrom Y, Visvesvara GS, Sriram R, da Silva AJ. Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. J Clin Microbiol. 2006;44:3589–95. DOIPubMedGoogle Scholar
Peng L, Zhou Q, Wu Y, Cao X, Lv Z, Su M, et al. A patient with granulomatous amoebic encephalitis caused by Balamuthia mandrillaris survived with two excisions and medication. BMC Infect Dis. 2022;22:54. DOIPubMedGoogle Scholar
Cuoco JA, Klein BJ, LeBel DP, Faulhaber J, Apfel LS, Witcher MR. Successful treatment of a Balamuthia mandrillaris cerebral abscess in a pediatric patient with complete surgical resection and antimicrobial therapy. Pediatr Infect Dis J. 2022;41:e54–7. DOIPubMedGoogle Scholar
Doyle JS, Campbell E, Fuller A, Spelman DW, Cameron R, Malham G, et al. Balamuthia mandrillaris brain abscess successfully treated with complete surgical excision and prolonged combination antimicrobial therapy. J Neurosurg. 2011;114:458–62. DOIPubMedGoogle Scholar
Botterill E, Yip G. A rare survivor of Balamuthia granulomatous encephalitis. Clin Neurol Neurosurg. 2011;113:499–502. DOIPubMedGoogle Scholar
Mei J, Sheng F, Zhang C, Chen X. Corrigendum to “Imaging monitoring of Balamuthia granulomatous amoebic encephalitis”. Clin Neurol Neurosurg. 2025;256:109015. DOIPubMedGoogle Scholar
Guarner J, Bartlett J, Shieh WJ, Paddock CD, Visvesvara GS, Zaki SR. Histopathologic spectrum and immunohistochemical diagnosis of amebic meningoencephalitis. Mod Pathol. 2007;20:1230–7. DOIPubMedGoogle Scholar
Dubey P, Kobpornchai P, Tongkrajang N, Chaiyaloom S, Lu C, Rice CA, et al. Drug susceptibility of a clinical isolate of Balamuthia mandrillaris, a pathogenic free-living amoeba. Antimicrob Agents Chemother. 2026;70:e0148225. DOIPubMedGoogle Scholar
Aboubechara JP, Kantamneni T, Pasao K. Balamuthia Mandrillaris central nervous system vasculitis in an immunocompetent child: case report. J Child Neurol. 2025;40:366–70. DOIPubMedGoogle Scholar
Degese MF, Prieto MP, Nigro MG, Perazzo J, Pérez Garófalo M, Lemir G, et al. Free-living amoebae infections: case reports identified at a reference parasitology laboratory in Argentina. Acta Parasitol. 2025;70:240. DOIPubMedGoogle Scholar
Vollmer ME, Glaser CA. Balamuthia survivor. JMM Case Rep. 2016;3:e005031. DOIPubMedGoogle Scholar
Deetz TR, Sawyer MH, Billman G, Schuster FL, Visvesvara GS. Successful treatment of Balamuthia amoebic encephalitis: presentation of 2 cases. Clin Infect Dis. 2003;37:1304–12. DOIPubMedGoogle Scholar
Schuster FL, Yagi S, Gavali S, Michelson D, Raghavan R, Blomquist I, et al. Under the radar: Balamuthia amebic encephalitis. Clin Infect Dis. 2009;48:879–87. DOIPubMedGoogle Scholar
Cary LC, Maul E, Potter C, Wong P, Nelson PT, Given CII, et al. Balamuthia mandrillaris meningoencephalitis: survival of a pediatric patient. Pediatrics. 2010;125:e699–703. DOIPubMedGoogle Scholar
Moriarty P, Burke C, McCrossin D, Campbell R, Cherian S, Shahab MS, et al. Balamuthia mandrillaris encephalitis: survival of a child with severe meningoencephalitis and review of the literature. J Pediatric Infect Dis Soc. 2014;3:e4–9. DOIPubMedGoogle Scholar
Orozco L, Hanigan W, Khan M, Fratkin J, Lee M. Neurosurgical intervention in the diagnosis and treatment of Balamuthia mandrillaris encephalitis. J Neurosurg. 2011;115:636–40. DOIPubMedGoogle Scholar
Yang Y, Hu X, Min L, Dong X, Guan Y. Balamuthia mandrillaris–related primary amoebic encephalitis in China diagnosed by next generation sequencing and a review of the literature. Lab Med. 2020;51:e20–6. DOIPubMedGoogle Scholar
Yi Z, Zhong J, Wu H, Li X, Chen Y, Chen H, et al. Balamuthia mandrillaris encephalitis in a child: case report and literature review. Diagn Microbiol Infect Dis. 2021;100:115180. DOIPubMedGoogle Scholar
Hu J, Zhang Y, Yu Y, Yu H, Guo S, Shi D, et al. Encephalomyelitis caused by Balamuthia mandrillaris in a woman with breast cancer: a case report and review of the literature. Front Immunol. 2022;12:768065. DOIPubMedGoogle Scholar
American Academy of Pediatrics Committee on Infectious Diseases. Kimberlin DW, Banerjee R, Barnett ED, Lynfield R, Sawyer MH, editors. Red Book: 2024–2027 Report of the Committee on Infectious Diseases. 33rd edition. Elk Grove Village (IL): American Academy of Pediatrics; 2024.
