Rolly Romero looks to defend his WBA welterweight championship when he battles former lightweight champion Teofimo Lopez in a 12-round boxing main event on Saturday. The main card is set for 8 p.m. ET from T-Mobile Arena, and the pay-per-view broadcast will be shown on DAZN and Prime Video. Romero is back in action after more than a year layoff after earning a unanimous decision win over Ryan Garcia on May 2, 2025, in Times Square in New York. Lopez, meanwhile, is coming off a unanimous decision loss to Shakur Stevenson on Jan. 31 at Madison Square Garden in New York.
Lopez is a -280 betting favorite (risk $280 to win $100), while Romero is priced at +205 (risk $100 to win $205) in the latest boxing odds for Rolando Romero vs. Teofimo Lopez. The over/under for total rounds completed is 11.5. Before locking in your Rolly Romero vs. Teofimo Lopez picks, make sure you see the Romero vs. Lopez predictions and betting advice from SportsLine expert Josh Nagel.
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Nagel, who is the combat sports editor for SportsLine, is an experienced and successful boxing analyst. He is SportsLine’s main boxing analyst and covered the sport for multiple outlets for more than 20 years, and had a massively profitable 2025 campaign. Perhaps his biggest winner was calling Terence Crawford (+140) against Canelo Alvarez in their September mega fight, while also correctly advising SportsLine members to take Crawford specifically by decision (+220). Anyone who has followed Nagel’s combat sports picks this year could already be up more than $2,500.
Now, with the Romero vs. Lopez fight card approaching, Nagel has studied Rolly Romero vs. Teofimo Lopez from every angle and revealed his top betting picks and best bets. Head to SportsLine to see them.
Rolly Romero vs. Teofimo Lopez preview
Romero, 30, previously held the WBA super lightweight crown from 2023 to 2024, and the WBA interim lightweight title in August 2020. In 19 career fights, he is 17-2, including 13 wins by knockout and four by decision. His losses have both come by knockout. Romero began his boxing career in December 2016, when he defeated David Courtney by TKO.
Romero proceded to win his next 10 bouts, before earning a unanimous decision win over Jackson Marinez for the vacant WBA interim lightweight title. On July 17, 2021, he knocked out Anthony Yigit at 1:54 of the seventh round to move his overall record to 14-0. He suffered his first loss to Gervonta Davis on May 28, 2022, in a WBA (regular) lightweight title bout. He is currently on a two-bout winning streak. Check out SportsLine to see Nagel’s picks and analysis.
Lopez, 29, has held multiple world championships in two weight classes. He had held the unified lightweight championship and the WBO junior welterweight crown. He also held The Ring Magazine lightweight and junior welterweight titles. In 24 career fights, Lopez is 22-2. He has registered 13 wins by knockout and nine by decision. His only two losses were both by decision.
Lopez opened his professional career with a knockout win over Ishwar Siqueiros on Nov. 5, 2016. On July 14, 2018, he earned a TKO win over William Silva 15 seconds into the sixth round to win the vacant WBC Continental Americas lightweight championship. He won his first 16 bouts before suffering his first loss to George Kambosos Jr. by split decision. He won his next six bouts before suffering the loss this past January. You can only see Nagel’s picks and analysis at SportsLine.
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Rolly Romero vs. Teofimo Lopez predictions
One of of Nagel’s Romero vs. Lopez picks: He is backing Over 11.5 total rounds in Romero vs. Lopez, which returns -400.
“Lopez became an overnight star on the strength of his massive upset of Vasiliy Lomachenko, who at the time was widely perceived as borderline invincible, in their October 2020 clash for the undisputed lightweight title. Unfortunately for Lopez, he lost most of his momentum with a similarly stunning upset loss to relatively unknown prospect George Kambosos a year later. Although his talent is undeniable, his performance trajectory has become a bit unpredictable.” See Nagel’s best bets for the fight at SportsLine.
How to make Romero vs. Lopez picks
Nagel also has strong picks for Romero vs. Lopez, including one on the money line and a method-of-victory prop. He’s sharing who it is only at SportsLine.
Who wins Romero vs. Lopez, and how exactly does the fight end? Visit SportsLine now to get detailed picks and analysis from the incomparable expert who is up over $2,500 on his combat sports picks last year, and find out.
