Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycoses. 2008;51(Suppl 4):2–15. DOIPubMedGoogle Scholar
Chanyachailert P, Leeyaphan C, Bunyaratavej S. Cutaneous fungal infections caused by dermatophytes and non-dermatophytes: an updated comprehensive review of epidemiology, clinical presentations, and diagnostic testing. J Fungi (Basel). 2023;9:669. DOIPubMedGoogle Scholar
Khan SS, Saunte DML. Dermatophyte treatment failure: a rapid global response to an emerging global health issue. Acta Derm Venereol. 2025;105:adv42948. DOIPubMedGoogle Scholar
Astvad KMT, Hare RK, Jørgensen KM, Saunte DML, Thomsen PK, Arendrup MC. Increasing terbinafine resistance in Danish Trichophyton isolates 2019–2020. J Fungi (Basel). 2022;8:150. DOIPubMedGoogle Scholar
Gupta AK. Susmita, Nguyen HC, Liddy A, Economopoulos V, Wang T. Terbinafine resistance in Trichophyton rubrum and Trichophyton indotineae: a literature review. Antibiotics (Basel). 2025;14:472. DOIPubMedGoogle Scholar
Mohseni S, Abou-Chakra N, Oldberg K, Chryssanthou E, Young E. Terbinafine resistant Trichophyton indotineae in Sweden. Acta Derm Venereol. 2025;105:adv42089. DOIPubMedGoogle Scholar
Gupta AK, Mays RR, Versteeg SG, Shear NH, Piguet V. Update on current approaches to diagnosis and treatment of onychomycosis. Expert Rev Anti Infect Ther. 2018;16:929–38. DOIPubMedGoogle Scholar
Schoch CL, Seifert KA, Huhndorf S, Robert V, Spouge JL, Levesque CA, et al.; Fungal Barcoding Consortium. Fungal Barcoding Consortium Author List. Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for fungi. Proc Natl Acad Sci U S A. 2012;109:6241–6. DOIPubMedGoogle Scholar
Tang C, Ahmed SA, Deng S, Zhang L, Zoll J, Al-Hatmi AMS, et al. Detection of emerging genotypes in Trichophyton mentagrophytes species complex: a proposal for handling biodiversity in dermatophytes. Front Microbiol. 2022;13:960190. DOIPubMedGoogle Scholar
Pchelin IM, Zlatogursky VV, Rudneva MV, Chilina GA, Rezaei-Matehkolaei A, Lavnikevich DM, et al. Reconstruction of phylogenetic relationships in dermatomycete genus Trichophyton Malmsten 1848 based on ribosomal internal transcribed spacer region, partial 28S rRNA and beta-tubulin genes sequences. Mycoses. 2016;59:566–75. DOIPubMedGoogle Scholar
P C, Lyngdoh V, Gogoi N, Gandhi S, Lyngdoh DL, Lanong S, et al. Molecular characterization of dermatophytes isolated in a tertiary care hospital in the north eastern part of India. Cureus. 2024;16:e74815.PubMedGoogle Scholar
Tang C, Kong X, Ahmed SA, Thakur R, Chowdhary A, Nenoff P, et al. Taxonomy of the Trichophyton mentagrophytes/T. interdigitale species complex harboring the highly virulent, multiresistant genotype T. indotineae. Mycopathologia. 2021;186:315–26. DOIPubMedGoogle Scholar
Baron A, Hamane S, Gits-Muselli M, Legendre L, Benderdouche M, Mingui A, et al. Dual quantitative PCR assays for the rapid detection of Trichophyton indotineae from clinical samples. Med Mycol. 2024;62:myae067. DOIPubMedGoogle Scholar
Singh A, Masih A, Monroy-Nieto J, Singh PK, Bowers J, Travis J, et al. A unique multidrug-resistant clonal Trichophyton population distinct from Trichophyton mentagrophytes/Trichophyton interdigitale complex causing an ongoing alarming dermatophytosis outbreak in India: genomic insights and resistance profile. Fungal Genet Biol. 2019;133:103266. DOIPubMedGoogle Scholar
Singh A, Singh P, Dingemans G, Meis JF, Chowdhary A. Evaluation of DermaGenius resistance real-time polymerase chain reaction for rapid detection of terbinafine-resistant Trichophyton species. Mycoses. 2021;64:721–6. DOIPubMedGoogle Scholar
Kano R, Kimura U, Kakurai M, Hiruma J, Kamata H, Suga Y, et al. Trichophyton indotineae sp. nov.: a new highly terbinafine-resistant anthropophilic dermatophyte species. Mycopathologia. 2020;185:947–58. DOIPubMedGoogle Scholar
Yamada T, Maeda M, Alshahni MM, Tanaka R, Yaguchi T, Bontems O, et al. Terbinafine resistance of Trichophyton clinical isolates caused by specific point mutations in the squalene epoxidase gene. Antimicrob Agents Chemother. 2017;61:e00115–7. DOIPubMedGoogle Scholar
Kong X, Tang C, Singh A, Ahmed SA, Al-Hatmi AMS, Chowdhary A, et al. Antifungal susceptibility and mutations in the squalene epoxidase gene in dermatophytes of the Trichophyton mentagrophytes species complex. Antimicrob Agents Chemother. 2021;65:e0005621. DOIPubMedGoogle Scholar
Blanchard G, Amarov B, Fratti M, Salamin K, Bontems O, Chang YT, et al. Reliable and rapid identification of terbinafine resistance in dermatophytic nail and skin infections. J Eur Acad Dermatol Venereol. 2023;37:2080–9. DOIPubMedGoogle Scholar
Singh A, Masih A, Khurana A, Singh PK, Gupta M, Hagen F, et al. High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the squalene epoxidase gene. Mycoses. 2018;61:477–84. DOIPubMedGoogle Scholar
Gupta AK, Cooper EA, Wang T, Polla Ravi S, Lincoln SA, Piguet V, et al. Detection of squalene epoxidase mutations in United States patients with onychomycosis: implications for management. J Invest Dermatol. 2023;143:2476–2483.e7. DOIPubMedGoogle Scholar
Gräser Y, El Fari M, Vilgalys R, Kuijpers AF, De Hoog GS, Presber W, et al. Phylogeny and taxonomy of the family Arthrodermataceae (dermatophytes) using sequence analysis of the ribosomal ITS region. Med Mycol. 1999;37:105–14. DOIPubMedGoogle Scholar
Brillowska-Dąbrowska A, Saunte DM, Arendrup MC. Five-hour diagnosis of dermatophyte nail infections with specific detection of Trichophyton rubrum. J Clin Microbiol. 2007;45:1200–4. DOIPubMedGoogle Scholar
Arendrup MC, Kahlmeter G, Guinea J, Meletiadis J; Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST). How to perform antifungal susceptibility testing of microconidia-forming dermatophytes following the new reference EUCAST method E.Def 11.0, exemplified by Trichophyton. Clin Microbiol Infect. 2021;27:55–60. DOIPubMedGoogle Scholar
EUCAST European Committee on Antimicrobial Susceptibility Testing. Clinical breakpoint table (yeasts and moulds) [cited 2026 Apr 16]. https://www.eucast.org/fungi-afst/clinical-breakpoints-and-interpretation/clinical-breakpoint-table
Baert F, Lefevere P, D’hooge E, Stubbe D, Packeu A. A polyphasic approach to classification and identification of species within the Trichophyton benhamiae complex. J Fungi (Basel). 2021;7:602. DOIPubMedGoogle Scholar
Padyana AK, Gross S, Jin L, Cianchetta G, Narayanaswamy R, Wang F, et al. Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun. 2019;10:97. DOIPubMedGoogle Scholar
Ferreira CB, Lisboa C. A systematic review on the emergence of terbinafine-resistant Trichophyton indotineae in Europe: time to act? J Eur Acad Dermatol Venereol. 2025;39:364–76. DOIPubMedGoogle Scholar
Dos Santos AR, Uhrlaß S, Nenoff P, Gold JAW, Bhuiyan MSI, Goturu S, et al. Global emergence of antifungal-resistant dermatophytosis caused by Trichophyton indotineae (formerly T. mentagrophytes ITS genotype VIII): a genomic investigation involving 14 countries. Mycoses. 2025;68:e70101. DOIPubMedGoogle Scholar
Astvad KMT, Saunte DML. Sexual transmission of a new emerging dermatophyte: T. mentagrophytes genotype VII. J Eur Acad Dermatol Venereol. 2025;39:245–6. DOIPubMedGoogle Scholar
El-Baba M, Hall CW, Armstrong I, Woodward K. Two cases of sexually transmitted Trichophyton indotineae. CMAJ. 2026;198:E10–2. DOIPubMedGoogle Scholar
Jabet A, Chiarabini T, Hennequin C, Bouscarat F, Valin N, Cruchet R, et al. Autochthonous transmission of Trichophyton indotineae through sexual contact, France, 2024. Euro Surveill. 2025;30:2500416. DOIPubMedGoogle Scholar
Jabet A, Dellière S, Seang S, Chermak A, Schneider L, Chiarabini T, et al. Sexually transmitted Trichophyton mentagrophytes genotype VII Infection among men who have sex with men. Emerg Infect Dis. 2023;29:1411–4. DOIPubMedGoogle Scholar
de Hoog GS, Dukik K, Monod M, Packeu A, Stubbe D, Hendrickx M, et al. Toward a novel multilocus phylogenetic taxonomy for the dermatophytes. Mycopathologia. 2017;182:5–31. DOIPubMedGoogle Scholar
Gräser Y, Scott J, Summerbell R. The new species concept in dermatophytes—a polyphasic approach. Mycopathologia. 2008;166:239–56. DOIPubMedGoogle Scholar
Nenoff P, Uhrlaß S, Verma SB, Panda S. Trichophyton mentagrophytes ITS genotype VIII and Trichophyton indotineae: a terminological maze, or is it? Indian J Dermatol Venereol Leprol. 2022;88:586–9. DOIPubMedGoogle Scholar
Chowdhary A, Singh A, Kaur A, Khurana A. The emergence and worldwide spread of the species Trichophyton indotineae causing difficult-to-treat dermatophytosis: A new challenge in the management of dermatophytosis. PLoS Pathog. 2022;18:e1010795.PubMedGoogle Scholar
Su H, Packeu A, Ahmed SA, Al-Hatmi AMS, Blechert O, İlkit M, et al. Species distinction in the Trichophyton rubrum complex. J Clin Microbiol. 2019;57:e00352–19.PubMedGoogle Scholar
Mirhendi H, Makimura K, de Hoog GS, Rezaei-Matehkolaei A, Najafzadeh MJ, Umeda Y, et al. Translation elongation factor 1-α gene as a potential taxonomic and identification marker in dermatophytes. Med Mycol. 2015;53:215–24.PubMedGoogle Scholar
Rezaei-Matehkolaei A, Mirhendi H, Makimura K, de Hoog GS, Satoh K, Najafzadeh MJ, et al. Nucleotide sequence analysis of beta tubulin gene in a wide range of dermatophytes. Med Mycol. 2014;52:674–88. DOIPubMedGoogle Scholar
Ahmadi B, Mirhendi H, Makimura K, de Hoog GS, Shidfar MR, Nouripour-Sisakht S, et al. Phylogenetic analysis of dermatophyte species using DNA sequence polymorphism in calmodulin gene. Med Mycol. 2016;54:500–14. DOIPubMedGoogle Scholar
Rudramurthy SM, Shaw D, Shankarnarayan SA. Abhishek, Dogra S. Comprehensive taxonomical analysis of Trichophyton mentagrophytes/interdigitale complex of human and animal origin from India. J Fungi (Basel). 2023;9:577. DOIPubMedGoogle Scholar
Uhrlaß S, Verma SB, Gräser Y, Rezaei-Matehkolaei A, Hatami M, Schaller M, et al. Trichophyton indotineae—an emerging pathogen causing recalcitrant dermatophytoses in India and worldwide—a multidimensional perspective. J Fungi (Basel). 2022;8:757. DOIPubMedGoogle Scholar
Sacheli R, Egrek S, El Moussaoui K, Kurt B, Machowski E, Harag S, et al. National Belgian study on terbinafine resistance in Trichophyton interdigitale/mentagrophytes/indotineae (2022–2023): epidemiology and molecular features. J Fungi (Basel). 2025;11:676. DOIPubMedGoogle Scholar
Sacheli R, Hayette MP. Antifungal resistance in dermatophytes: genetic considerations, clinical presentations and alternative therapies. J Fungi (Basel). 2021;7:983. DOIPubMedGoogle Scholar
Kumar P, Ramachandran S, Das S, Bhattacharya SN, Taneja B. Insights into changing dermatophyte spectrum in India through analysis of cumulative 161,245 cases between 1939 and 2021. Mycopathologia. 2023;188:183–202. DOIPubMedGoogle Scholar






